College Papers

Positron previous studies have shown a good diagnostic

Positron emission tomography (PET)/magnetic resonance imaging (MRI) is a
hybrid imaging technique that allows the simultaneous acquisition of
quantitative PET and MR data concerning biological processes.1 Because
of the high contrast resolution in the head and neck region, the use of MRI in
combination with PET could play a crucial role in the evaluation of HNSCC eextension
and nodal involvement, as well as in the detection of distant metastasis and
for treatment monitoring. A multiparametric approach to analyze pretreatment Diffusion-weighted
Imaging (DWI) and Dynamic Contrast Enhanced (DCE) MRI of primary tumors and
nodal lesions are promising to accurately predict local treatment response to
chemoradiation therapy in HNSCC and particularly Ktrans has been reported as a potential
noninvasive biomarker for predicting therapeutic response in HNSCC. 2,3
In this setting, high Apparent Diffusion Coefficient (ADC) from DWI and low
Ktrans from DCE-MRI in pre-treatment head and neck sites have been associated with
unfavourable treatment outcomes; however, clinical thresholds have yet to be established
and research into the optimum methods for data acquisition and analysis are
still ongoing.4 Moreover, previous studies have shown a good
diagnostic accuracy of PET/computed tomography (CT) in the assessment of
treatment response after definitive CHT/RT for HNSCC with the potential to
guide clinical decision-making.5 Thus, some studies have suggested
that a combined approach of PET and MRI may provide a better assessment of
tumor microenvironment.6 In this short report we aimed to extract metabolic
and functional PET/MR parameters of 5 patients with locally advanced HNSCC before
and after chemo (CHT) and/or radiotherapy (RT), in order to assess the response
to treatment according to the clinical evaluation and to possibly identify
biomarkers predictive of the response.